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- W2356139671 abstract "Objective:Retrospectively analyze the long-term results of pediatric nasopharynx cancer.The strategies of treatment are also to be discussed.Methods:Thirty five cases with pediatric nasopharynx cancer treated in our hospital from 1986 to 2000 were observed,18 patients received radiotherapy alone(group RT),18 chemotherapy plus radiotherapy(group C+RT),13 cases were treated with radiation doses ≤60 Gy while 22 received 60 Gy.All the 13 relapses were treated by salvage chemotherapy,added or not by a palliative radiotherapy.Results:The patients of pediatric nasopharynx cancer(NPC) counted for 0.4% of all the patients of NPC treated at the same period in our hospital.The most frequent(91.4%) pathological type was high-grade squamous carcinoma.88.6% was in stages III+IV when admission.The 5-year overall survival(OS) for all patients was 57.1%.The 5-year progression free survival(PFS) of group C+RT and group RT were 94.1% and 44.4%,respectively,P=0.003,thus improving the 5-year OS,which were 76.5% and 38.9%,respectively,P=0.04.The 5-year locally relapse-free survival(LFRS) of those treated with radiation doses 60 Gy and ≤60 Gy was 72.7% vs 30.8%,P=0.02,and OS 90.9% vs 53.8%,P=0.004.The overall relapse rate was 37.1%,and mean survival of 32 months was obtained after re-treated.The rate of serious side effects was 14.3%,all occurred in patients treating dose 60 Gy,and 80% was found in group C+RT.Conclusion:Pediatric nasopharynx cancer has a good prognosis,although most of the patients have been in advanced stage when admission.Induction chemotherapy could decrease the rate of distant metastases and increase survival.It is reasonable to select treaiting dose 60 Gy to ensure a good local control.In order to avoid the serious adverse events,the dose should not be too high and a dose of 60Gy~65 Gy is proposed.In case of relapse,a good result could be achieved by salvage treatment." @default.
- W2356139671 created "2016-06-24" @default.
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- W2356139671 date "2007-01-01" @default.
- W2356139671 modified "2023-09-26" @default.
- W2356139671 title "An analysis of the long-term results of pediatric nasopharynx cancer" @default.
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