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- W2356157488 abstract "Objective To explore the clinical characteristics and influential factors on prognosis of hemophagocytic lymphohistiocytosis(HLH)in children.Methods Sixty-four children with HLH were registered in this study group from Jan.2004 to May 2007.Of these,twenty-one cases were girls and 43 cases were boys;the median age at diagnosis was 4 years and 3 months.Apart from items needed by the diagnosis,brain computer tomography(CT)or magnetic resonance imaging(MRI),cerebrospinal fluid analysis and antibodies of Epstein-Barr virus(EBV),cytomegalovirus,herpes simplex virus,Coxsackie virus,echo virus were detested prior chemotherapy routinely.All examinations above mentioned were monitored regularly.All patients were adopted the same immunochemotherapy protocol.Results 1.One child died and 4 children gave up therapy in 8 weeks after therapy without assessment.The rest 59 children showed improvement,and of these 21 children gave up therapy later on because of various reasons.Thirty-two children were off-therapy,and among them 3 children relapsed in 1 month.2.Altogether 47 children(73.4%)had EBV infection,also EBV associated HLH(EBV-HLH).Among the 29 children with unfavourable result(death and relapse),24 children(82.7%)were EBV-HLH.3.Altogether 60 children(93.8%)had central nervous system(CNS)involvement and neuroradiological changes precede clinical manifestations.Conclusions 1.Majority of children in this study were prone to be secondary HLH.2.EBV-HLH is the main type of the secondary HLH in our country,and also is one of critical unfavourable prognosis factors.3.CNS involvement in HLH has a very high frequency and poor prognosis.But that nonetheless there is still hope to recover completely as long as proper chemotherapy treatment is applied at an early stage.4.Now that brain MRI changes can precede neurological symptoms,all children should have a MRI performed routinely from diagnosis." @default.
- W2356157488 created "2016-06-24" @default.
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- W2356157488 date "2009-01-01" @default.
- W2356157488 modified "2023-09-23" @default.
- W2356157488 title "Prospective Study of Hemophagocytic Lymphohistiocytosis in Children" @default.
- W2356157488 hasPublicationYear "2009" @default.
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