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- W2356160220 abstract "Objective To study the effect of genomic HLA-DR compatibility on long-term survival in renal transplantation.Methods A retrospective study was performed on 518 first-cadaver renal transplants by using genotyping technique.Results More than 10%recipients shared HLA-DR matching at DNA level.half of 1 DR mismatches.The recipients with HLA-DR matched transplants showed a significant decrease of acute rejection episodes and a smooth recovery of early renal function as compared with those of DR mismatching kidneys.The 1 to 5 year-person survival rate was increased by 17%to 37.7% (P＜0.01)respectively.Multivariate analysis of 10 variables by Cox regression model revealed that DR mismatching was the most important factors influencing the long-term graft survival.Conclusion Genomic HLA-DR compatibility had a significant impact on long-term survival of first-cadaver kidney transplantation.Key words: Renal transplantation; Histocompatibility; HLA-DR" @default.
- W2356160220 created "2016-06-24" @default.
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- W2356160220 date "2000-03-20" @default.
- W2356160220 modified "2023-09-23" @default.
- W2356160220 title "Effects of genomic HLA-DR compatibility on long-term survival in first-cadaver kidney transplants" @default.
- W2356160220 doi "https://doi.org/10.3760/cma.j.issn.0254-1785.2000.02.018" @default.
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