Matches in SemOpenAlex for { <https://semopenalex.org/work/W2356166959> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2356166959 abstract "Objective To observe the contents of endothelin(ET) in plasma urine and renal tissue of diabetic rats and their significance. Methods Diabetic mellitus was induced by an intraperitoneal injection of streptozotocin (50 mg/kg) in rats. Renal damages and changes of endothelin in plasma, urine and renal tissue were observed. Results After 12 weeks of hyperglycemia, endogenous creatinine clearance rate, blood urea nitrogen, and 24 hour urinary protein excretion increased significantly and the body weight decreased in the diabetic rats when compared with controls. Extracellular martix accumulation and basement membrane thickening were seen with EM. Plasma ET of diabetic rats was lower than that of normal rats, but renal tissue ET and 24 hour urinary ET excretion were increased obviously. Conclusion Our study suggests: ①Increase of renal ET synthesis plays an important role in the pathogensis of diabetic nephropathy. ②Hyperglycemia has direct effect on the inhibition of the synthesis and release of endothelin in endothelial cells. ③The increased urine ET excretion in diabetes mellitus is related to the severity of the diabetic renal lesion and can be regarded as an early and sensitive marker of diabetic nephropathy." @default.
- W2356166959 created "2016-06-24" @default.
- W2356166959 creator A5009612195 @default.
- W2356166959 date "2002-01-01" @default.
- W2356166959 modified "2023-09-23" @default.
- W2356166959 title "Contents and significance of endothelin in plasma urine and renal tissue of diabetic rats" @default.
- W2356166959 hasPublicationYear "2002" @default.
- W2356166959 type Work @default.
- W2356166959 sameAs 2356166959 @default.
- W2356166959 citedByCount "0" @default.
- W2356166959 crossrefType "journal-article" @default.
- W2356166959 hasAuthorship W2356166959A5009612195 @default.
- W2356166959 hasConcept C10146269 @default.
- W2356166959 hasConcept C126322002 @default.
- W2356166959 hasConcept C134018914 @default.
- W2356166959 hasConcept C144980905 @default.
- W2356166959 hasConcept C159641895 @default.
- W2356166959 hasConcept C170493617 @default.
- W2356166959 hasConcept C2779280383 @default.
- W2356166959 hasConcept C2779922275 @default.
- W2356166959 hasConcept C2780026642 @default.
- W2356166959 hasConcept C2780091579 @default.
- W2356166959 hasConcept C2780306776 @default.
- W2356166959 hasConcept C2781184683 @default.
- W2356166959 hasConcept C555293320 @default.
- W2356166959 hasConcept C71924100 @default.
- W2356166959 hasConcept C77411442 @default.
- W2356166959 hasConceptScore W2356166959C10146269 @default.
- W2356166959 hasConceptScore W2356166959C126322002 @default.
- W2356166959 hasConceptScore W2356166959C134018914 @default.
- W2356166959 hasConceptScore W2356166959C144980905 @default.
- W2356166959 hasConceptScore W2356166959C159641895 @default.
- W2356166959 hasConceptScore W2356166959C170493617 @default.
- W2356166959 hasConceptScore W2356166959C2779280383 @default.
- W2356166959 hasConceptScore W2356166959C2779922275 @default.
- W2356166959 hasConceptScore W2356166959C2780026642 @default.
- W2356166959 hasConceptScore W2356166959C2780091579 @default.
- W2356166959 hasConceptScore W2356166959C2780306776 @default.
- W2356166959 hasConceptScore W2356166959C2781184683 @default.
- W2356166959 hasConceptScore W2356166959C555293320 @default.
- W2356166959 hasConceptScore W2356166959C71924100 @default.
- W2356166959 hasConceptScore W2356166959C77411442 @default.
- W2356166959 hasOpenAccess W2356166959 @default.
- W2356166959 hasRelatedWork W2012628372 @default.
- W2356166959 hasRelatedWork W2038044228 @default.
- W2356166959 hasRelatedWork W2051203316 @default.
- W2356166959 hasRelatedWork W2079668295 @default.
- W2356166959 hasRelatedWork W2181540743 @default.
- W2356166959 hasRelatedWork W2351670643 @default.
- W2356166959 hasRelatedWork W2353237162 @default.
- W2356166959 hasRelatedWork W2355837784 @default.
- W2356166959 hasRelatedWork W2356024788 @default.
- W2356166959 hasRelatedWork W2356858099 @default.
- W2356166959 hasRelatedWork W2359200767 @default.
- W2356166959 hasRelatedWork W2359345438 @default.
- W2356166959 hasRelatedWork W2360903037 @default.
- W2356166959 hasRelatedWork W2365757581 @default.
- W2356166959 hasRelatedWork W2375035930 @default.
- W2356166959 hasRelatedWork W2379707512 @default.
- W2356166959 hasRelatedWork W2387337727 @default.
- W2356166959 hasRelatedWork W2388187404 @default.
- W2356166959 hasRelatedWork W2392694406 @default.
- W2356166959 hasRelatedWork W2513479869 @default.
- W2356166959 isParatext "false" @default.
- W2356166959 isRetracted "false" @default.
- W2356166959 magId "2356166959" @default.
- W2356166959 workType "article" @default.