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- W2356177017 abstract "[Objective] To evaluate the possible roles of IL-18 in HBV infection, and investigate the relationship between IL-18 and the result of lamivudine treatment. [Methods] 50 patients infected with HBV (including 15 cases of asymptomatic carriers, 21 cases of chronic hepatitis, and 14 cases of severe hepatitis) and 10 healthy individuals (as normal controls) were chosen to detect their serum levels of IL-18 by ELISA method. Patients with CHB were also detected during Lamivudine treatment. [Results] There were significant differences in serum IL-18 level between every 2 types of HBV infection (P 0.01), the IL-18 level in patients with severe hepatitis was significantly higher than that in normal controls (P 0.01). Almost no difference existed between chronic hepatitis and normal controls (P 0.05). The IL-18 level in asymptomatic carriers was lower than that in normal controls (P 0.05). There was a positive correlation between the levels of IL-18 and ALT in patients with CHB (r =0.662, P =0.001). Significant difference appeared in serum IL-18 levels between patients with different amounts of HBV DNA, the IL-18 level of low amounts of HBV DNA being higher. In the course of lamivudine treatment, the IL-18 level in the group of HBV DNA negative conversion rose drastically three months after the treatment (P 0.05) and fell significantly twelve months later (P0.01), compared with those without any treatment. [Conclusion] IL-18 may involve in the process of liver inflammatory injury and HBV immuno-elimination in patients with HBV infection. Lamivudine treatment can promote Th1 immune responses." @default.
- W2356177017 created "2016-06-24" @default.
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- W2356177017 date "2008-01-01" @default.
- W2356177017 modified "2023-09-27" @default.
- W2356177017 title "Relationship of IL-18 levels, HBV infection, and Lamivudine treatment in chronic hepatitis B" @default.
- W2356177017 hasPublicationYear "2008" @default.
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