FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2356183854> ?p ?o ?g. }

• W2356183854 endingPage "779" @default.
• W2356183854 startingPage "772" @default.
• W2356183854 abstract "Blastocystis spp. are commonly reported intestinal protists but whose clinical significance remains controversial. Infections have ranged from asymptomatic carriage to non-specific gastrointestinal symptoms and have also been linked to irritable bowel syndrome and urticaria in some patient populations. In vitro studies showed that both parasite and parasite lysates have damaging effects on intestinal epithelial cells causing apoptosis and degradation of tight junction proteins occludin and ZO1, resulting in increased intestinal permeability. Adhesion of trophic forms to the intestinal epithelium and release of cysteine proteases appear to be the major triggers leading to pathogenesis. Two putative virulence factors identified are cysteine proteases legumain and cathepsin B. Blastocystis spp. also have immuno-modulatory effects including degradation of IgA, inhibition of iNOS and upregulation of proinflammatory cytokines, IL8 and GM-CSF in intestinal epithelial cells and IL1β, IL6 and TNFα in murine macrophages. Blastocystis spp. have also been reported to dampen response to LPS in intestinal epithelial cells and monocytes. Studies in rodent models and naturally infected pigs have shown that the parasite localizes to the lumen and mucosal surface of the large intestine mostly in the caecum and colon. The parasite has been found to cause mucosal sloughing, increase in goblet cell mucin, increased intestinal permeability and to induce a pro-inflammatory cytokine response with upregulation of TNFα, IFNγ and IL12. In this review, we summarize findings from in vitro and in vivo studies that demonstrate pathogenic potential but also show considerable inter and intra subtype variation, which provides a plausible explanation on the conflicting reports on clinical significance." @default.
• W2356183854 created "2016-06-24" @default.
• W2356183854 creator A5043093379 @default.
• W2356183854 creator A5078621129 @default.
• W2356183854 date "2016-12-01" @default.
• W2356183854 modified "2023-10-14" @default.
• W2356183854 title "Pathogenic mechanisms in Blastocystis spp. — Interpreting results from in vitro and in vivo studies" @default.
• W2356183854 cites W1538459559 @default.
• W2356183854 cites W1966504489 @default.
• W2356183854 cites W1969575377 @default.
• W2356183854 cites W1970268087 @default.
• W2356183854 cites W1975136503 @default.
• W2356183854 cites W1976447738 @default.
• W2356183854 cites W1978978323 @default.
• W2356183854 cites W1982152447 @default.
• W2356183854 cites W1986298377 @default.
• W2356183854 cites W1986588307 @default.
• W2356183854 cites W1988758033 @default.
• W2356183854 cites W1991522326 @default.
• W2356183854 cites W1991680568 @default.
• W2356183854 cites W1991723636 @default.
• W2356183854 cites W1991918472 @default.
• W2356183854 cites W1992407739 @default.
• W2356183854 cites W1994210081 @default.
• W2356183854 cites W2003332736 @default.
• W2356183854 cites W2005746394 @default.
• W2356183854 cites W2006556033 @default.
• W2356183854 cites W2011671893 @default.
• W2356183854 cites W2014982880 @default.
• W2356183854 cites W2016997092 @default.
• W2356183854 cites W2018033203 @default.
• W2356183854 cites W2027929810 @default.
• W2356183854 cites W2030148103 @default.
• W2356183854 cites W2030269857 @default.
• W2356183854 cites W2032475147 @default.
• W2356183854 cites W2033649818 @default.
• W2356183854 cites W2044285259 @default.
• W2356183854 cites W2044441310 @default.
• W2356183854 cites W2044768627 @default.
• W2356183854 cites W2047864640 @default.
• W2356183854 cites W2048181898 @default.
• W2356183854 cites W2049026996 @default.
• W2356183854 cites W2061077466 @default.
• W2356183854 cites W2063367588 @default.
• W2356183854 cites W2064264230 @default.
• W2356183854 cites W2072188034 @default.
• W2356183854 cites W2072475972 @default.
• W2356183854 cites W2075067862 @default.
• W2356183854 cites W2075928784 @default.
• W2356183854 cites W2077907846 @default.
• W2356183854 cites W2082654499 @default.
• W2356183854 cites W2082880033 @default.
• W2356183854 cites W2089224896 @default.
• W2356183854 cites W2092846008 @default.
• W2356183854 cites W2092988231 @default.
• W2356183854 cites W2096292402 @default.
• W2356183854 cites W2098021502 @default.
• W2356183854 cites W2112154582 @default.
• W2356183854 cites W2114998906 @default.
• W2356183854 cites W2116269514 @default.
• W2356183854 cites W2137526386 @default.
• W2356183854 cites W2140949777 @default.
• W2356183854 cites W2141125135 @default.
• W2356183854 cites W2141761277 @default.
• W2356183854 cites W2152505171 @default.
• W2356183854 cites W2152812038 @default.
• W2356183854 cites W2155320385 @default.
• W2356183854 cites W2159040157 @default.
• W2356183854 cites W2160427418 @default.
• W2356183854 cites W2160616422 @default.
• W2356183854 cites W2161258791 @default.
• W2356183854 cites W2162992036 @default.
• W2356183854 cites W2167512022 @default.
• W2356183854 cites W2169494411 @default.
• W2356183854 cites W2215723365 @default.
• W2356183854 doi "https://doi.org/10.1016/j.parint.2016.05.007" @default.
• W2356183854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27181702" @default.
• W2356183854 hasPublicationYear "2016" @default.
• W2356183854 type Work @default.
• W2356183854 sameAs 2356183854 @default.
• W2356183854 citedByCount "104" @default.
• W2356183854 countsByYear W23561838542016 @default.
• W2356183854 countsByYear W23561838542017 @default.
• W2356183854 countsByYear W23561838542018 @default.
• W2356183854 countsByYear W23561838542019 @default.
• W2356183854 countsByYear W23561838542020 @default.
• W2356183854 countsByYear W23561838542021 @default.
• W2356183854 countsByYear W23561838542022 @default.
• W2356183854 countsByYear W23561838542023 @default.
• W2356183854 crossrefType "journal-article" @default.
• W2356183854 hasAuthorship W2356183854A5043093379 @default.
• W2356183854 hasAuthorship W2356183854A5078621129 @default.
• W2356183854 hasConcept C126322002 @default.
• W2356183854 hasConcept C150903083 @default.
• W2356183854 hasConcept C164027704 @default.
• W2356183854 hasConcept C177779419 @default.
• W2356183854 hasConcept C179264091 @default.
• W2356183854 hasConcept C181199279 @default.

• next