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- W2356199529 abstract "Objective: The preliminary study on the clinical significance of B-type natriuretic peptide,L-selectin,E-selectin plasma levels of the blood system malignant tumor patients in evaluation the anthracycline cardiac toxicity during chemotherapy.Method: We detected B-type natriuretic peptide(BNP)、L-selectin、E-selectin and creatine kinase(CK-MB)plasma levels of 22 cases treated with anthracycline pirarubicin(THP) of the blood cancer before and after chemotherapy.The cases were assigned to THP ≤ 180mg group,180mg THP ≤ 360mg group,360mg THP≤450mg group,THP 450mg group according to the anthracycline pirarubicin cumulative doses of THP of per square meter of body surface area.Comparative analysis of BNP、L-selectin、E-selectin and CK-MB plasma levels between the control group and before treatment group and normal group.Result: After anthracycline pirarubicin cumulative dose reach to 180mg-360mg per square meter of body surface area,The level of BNP,L-selectin and E-selectin in all control groups increased significantly compared with those the before treatment group(P 0.01),and there was a Continuously rising trend with the increasing of anthracycline pirarubicin accumulative dose.While the level of MB increased significantly only when the anthracycline pirarubicin accumulative dose per square meter of body surface area exceed 450mg compared with those in before treatment group(P 0.01).Conclusion: This study shows the plasma level of BNP,L-selectin and E-selectin were more sensitive than CK-MB in evaluation the anthracycline cardiac toxicity during chemotherapy of blood cancer,BNP is a sensitive index in evaluation the anthracycline cardiac toxicity,L-selectin and E-selectin maybe also is a sensitive index the same as BNP,which need to be further studied." @default.
- W2356199529 created "2016-06-24" @default.
- W2356199529 creator A5051065216 @default.
- W2356199529 date "2010-01-01" @default.
- W2356199529 modified "2023-09-24" @default.
- W2356199529 title "Preliminary Study on the Clinical Significance of B-type Natriuretic Peptide L-selectin E-selectin Plasma Levels of the Blood System Malignant Tumor Patients in Evaluation the Anthracycline Cardiac Toxicity During Chemotherapy" @default.
- W2356199529 hasPublicationYear "2010" @default.
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