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• W2356214656 abstract "Objective To study the regulatory mechanism of lipid metabolism disorders in the blood fat of hyperlipemia rat model with Olive Antihyperlipidemia Capsule, and do systematic observation on the functions of this medicine on lipids and high density lipoprotein receptor in rat liver gene expression, and then to clarify the mechanism of action of this medicine on treating hyperlipemia. Methods Select SD rats as investigated subject. The hyperlipemia rat models were made with feeding high-fat forage and were randomly divided into six groups based on the total cholesterol level at the rats’ fasting for 12 hours: group A, group B, group C, group D, group E and group F. Each group included eight rats. Group A was normal group, group B was model group, group C was Xue Zhi Kang group, and group D, E and F were Olive Antihyperlipidemia Capsule groups with low, medium and high dosage respectively. Group A was fed normal forage, but other groups were fed high fat forage. All groups were allowed to drink water freely. Since the first day when the models were made, intragastric administration had been adopted. Group A was fed normal forage without intragastric administration; group B was received physiological saline 1ml/kg.d with intragastric administration; group C received Xue Zhi Kang Capsule 0.09/kg·d with intragastric administration; Group D, E and F received Olive Antihyperlipidemia Capsule 0.675g/kg·d,1.35g/kg·d,2.7g/kg·d with intragastric administration respectively; each administered solution was 3ml,which comprised water and the certain medicine mentioned above, and administered for six weeks continuously. Each group was weighed once a week. At the end of the sixth week, and after the rats’ fasting for 12 hours, the rats was anesthetized with pentobarbital sodium (40mg/kg) through abdominal cavity, then the samples in the research were collected and examined the level of TC and TG in the blood serum by using enzyme; examined HDL-c, LDL-c by PTA-Mg2+ precipitation method; analyzed the changes of SR-B1 gene expression in rat’s liver by RT-PCR. Results Olive Antihyperlipidemia Capsule can markedly lower the level of TC,TG,LDC-C in the blood serum, raise the level HDL, enhance SR-B1 gene expression in rats’ liver and finally accomplish the purpose of reducing blood fat. The experiment shows this medicine has the remarkable effect on hyperlipidemia. Conclusion Olive Antihyperlipidemia Capsule has an applicable value on preventing the cause, enhancing SR-B1 gene expression in rats’ liver and finally accomplishing the purpose of reducing blood fat and development of hyperlipemia and its complications." @default.
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• W2356214656 date "2006-01-01" @default.
• W2356214656 modified "2023-09-27" @default.
• W2356214656 title "Effect of Olive Antihyperlipidemia Capsule on Lipids and High Density Lipoprotein ReceptorLiver Gene Expression in Rats" @default.
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