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- W2356221018 abstract "Objective To study the therapeutic efficacy of memantine(MEM)against acute toxicity of omethoate.Method(1)Soon after omethoate(20 mg/kg)were given to mice by gastrogavage,physiological saline,MEM(10 mg/kg)or atropine(15 mg/kg)were administered to three groups by intraperitoneal injection.Toxic signs and survival rate were recorded.(2)Soon after omethoate(40 mg/kg)were given to rats by gastrogavage,physiological saline or MEM(18 mg/kg)were intraperitoneally injected to two groups.Toxic signs and survival rate were recorded.Result(1)The decreased incidence rate of convulsion and dyspnea,the alleviated intensity and delayed onset of muscular fasciculation were seen in omethoate-exposed mice after MEM treatment as compared with non-treatment group.Survival rate was significantly higher in MEM treatment group than in non-treatment group(P0.05).(2)The onset of convulsion,dyspnea and muscular fasciculation were delayed and the survival rate was significantly increased in rats of MEM treatment group compared with non-treatment group.Conclusion MEM has therapeutic efficacy against acute toxicity of omethoate." @default.
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- W2356221018 date "2006-01-01" @default.
- W2356221018 modified "2023-09-22" @default.
- W2356221018 title "Experimental study on therapeutic efficacy of memantine against acute toxicity of omethoate" @default.
- W2356221018 hasPublicationYear "2006" @default.
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