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- W2356222020 abstract "Objective To evaluate the cognitive impairment,results of neuro-electrophysiological and magnetic resonance image(MRI) and to discuss the frequency,characteristic and mechanism of cognition disorder in patients with multiple sclerosis. Methods Twenty-eight patients with remitting-relapsing multiple sclerosis underwent Event-Related Potentials(ERP),MRI scan.Wechsler Intelligence Tests and Clinical Memory Scale were used to assess the degree of cognition and affective disorder.The incidence of cognitive disorder was observed and the correlation between the abnormalities and ERP and MRI was analyzed. Results Twenty patients(71.4%) had cognitive disorder,and 17(60.7%) patients′ full intelligence quotient(FIQ) and 18(64.3%) patients′ memory quotient(MQ) were abnormal.MRI lesion grade scale(respectively(2.5±1.6) and(1.4±1.5)) had no significant difference between those with and without intelligence damage according to Wechsler Intelligence Tests(lesion grade scores respectively(2.7±1.3) and(0.9±1.4),frontal lobe lesion grade scores respectively(1.11±0.83) and(0.40±0.84)),but they had significant difference(P0.05) according to Clinical Memory Scale.Comprehensive analysis showed that there was significant difference(P0.05) between those with and without cognitive impairment in lesion grade.The latent period of P300 had significant difference between those with and without cognitive impairment,but amplitude of P300 did not.By regression analysis,we found that EDSS and education time had a significant influence to FIQ,and MRI lesion grade scale and age had a significant influence to memory quotient. Conclusion Cognitive impairment has a high incidence in MS patients,and has a correlation with neurologic impairment and lesion grade.Event-Related Potentials is also an effective tool to evaluate cognitive function." @default.
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- W2356222020 date "2011-01-01" @default.
- W2356222020 modified "2023-09-23" @default.
- W2356222020 title "The Study of Cognitive Impairment in Patients with Multiple Sclerosis and Its Relationship with MRI and ERP" @default.
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