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- W2356223776 abstract "Objective To investigate the myocardial protective effect of ramipril and losartan potassium alone and combination in myocardial ischemia-reperfusion injury in mouse.Methods Forty mice were randomly divided into the ramipril group,losartan potassium group,the combination group and control group with each of 10,the production of ischemia-reperfusion injury model and intravenously 5 min before reperfusion ramipril,losartan potassium,ramipril+losartan potassium and saline.Results The MAP difference of ramipril,losartan potassium and combination group were significantly greater than the control group(P 0.01),the difference of MAP difference in combination group,ramipril group and losartan group were not statistically significant(P 0.05).IR/AR of ramipril,losartan potassium and combination group were significantly lower than the control group(P 0.01),the difference of them in combination group,ramipril group and losartan potassium group were not statistically significant(P 0.05).Conclusion Ramipril and losartan potassium on myocardial ischemia-reperfusion injury have myocardial protective effect,but combination with no better." @default.
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- W2356223776 date "2012-01-01" @default.
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- W2356223776 title "Effect of ramipril and losartan potassium on myocardial protection in myocardial ischemia-reperfusion injury in mouse" @default.
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