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- W2356224105 abstract "OBJECTIVE To establish mice model of allergic rhinitis(AR) and study the role of Staphylococcal enterotoxin B(SEB)and ovalbumin(OVA)in the model,and investigate the change of regulatory T cell(Treg)in the nasal mucosa of mice.METHODS Forty Balb/c mice were randomized into OVA group(A),SEB group(B),OVA+SEB group(C)and normal solution group(D).AR model was established.The symptom scores and count of Foxp3 positive cells in nasal mucosa were analyzed by factorial design.RESULTS The symptom scores in Group A,B,C,D were 0.90±0.99,0.70±0.82,6.80±1.03,0.60±0.70 respectively.Group C was successfully established as AR model.OVA and SEB had interaction(P0.01).Compared with the other three groups,Foxp3-positive cells in Group C was decreased significantly(P0.01).CONCLUTION Only OVA and SEB cooperation could induce AR.SEB can increase the susceptibility of OVA to the body and act as immunity adjuvant.The level of Treg cells in nasal mucosa obviously decreased and Treg cells can not effectively inhibit the Th2 cell reaction,which may be a reason in the AR development." @default.
- W2356224105 created "2016-06-24" @default.
- W2356224105 creator A5083566143 @default.
- W2356224105 date "2010-01-01" @default.
- W2356224105 modified "2023-09-29" @default.
- W2356224105 title "Effect of regulatory T cell in SEB/OVA allergic rhinitis of animal model" @default.
- W2356224105 hasPublicationYear "2010" @default.
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