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- W2356224504 abstract "Objective:To assess the relationship between change of serum basic fibroblast growth factor(bFGF)level and pulmonary arterial pressure and its intervention in patients with chronic cor pulmonale at high altitude areas(HACCP).Methods:Sixty patients with acute exacerbation of HACCP were randomly divided into 3 groups with 20 cases in each:a oxygen therapy group(combination routine and oxygen therapy),a rhodiola group(combination routine and rhodiola,2.0g of rhodiola was given orally,three times daily)and a routine therapy group(routine treatmlent).The levels of bFGF in serum were measured by ELISA,mean pulmonary arterial pressure(mPAP)was measured by echocardiography,and the PaO2 was measured by blood gas analyzer before and 3 weeks after treatment.Another,the upper mentioned parameters were measured in 30 patients with chronic obstructive pulmonary disease(COPD)and 30 healthy peoples.Results:The level of serum bFGF(87.54±12.15)pg·mL-1 and mPAP(45.86±5.63)mmHg in the patients with HACCP were significantly higher than those in the patients with COPD[(55.72±9.08)pg·mL-1,(22.95±2.56)mmHg,respectively,all P0.01),the patients with COPD were both significantly higher than those the healthy peoples[(49.83±8.78)pg·mL-1,(20.34±2.23)mmHg,respectively,all P0.01),The PaO2(38.79±4.56)mmHg in the patients with HACCP was significantly lower than that in patients with COPD and healthy peoples[(58.22±6.l8)mmHg and 66.57±5.48mmHg,respectively,all P0.01).The levels of serum bFGF In the patients with HACCP and the patients with COPD was positive correlated with mPAP(r=0.788,0.674,all P0.01),netatively correlated with PaO2(r=-0.735,-0.587,all P0.01).The after therapy,serum bFGF,mPAP and PaO2 in three groups of HACCP were all markedly improved compared with those before(all P0.01),Those parameters in oxygen therapy group were different markedly compared with those in rhodiola group,and the parameters in rhodiola group were different markedly compared with those in routine therapy group(all P0.05).Conclusion:The level of serum bFGF in patients with HACCP is significantly increased;it may play an important role In the process of sustained pulmonary hypertension In patients with HACCP.Treatments of oxygen and rhodiola can effectively inhibit serum bFGF and decrease PAP in patients with HACCP." @default.
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- W2356224504 date "2008-01-01" @default.
- W2356224504 modified "2023-09-25" @default.
- W2356224504 title "The Relationship between Change of Serum Basic Fibroblast Growth Factor Level and Pulmonary Arterial Pressure and Its Intervention in Patients with Chronic Cor Pulmonale at High Altitude Areas" @default.
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