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- W2356225260 abstract "Objective To explore the effects of antibiotics combined with corticosteroid on suppressing renal scarring in treatment-delayed chronic pyelonephrits (CPN). Methods An experimental CPN model in rats was developed. All animals were divided into five groups including group A (normal group), group B (model group), group C (Lev- ofloxacin Lactate/LFL treatment given 24h after operation), group D (delayed treatment with LFL and methylprednisone giv- en 72h after operation) and group E (delayed treatment with LFL given 72h after operation). Urine N-acety1-beta –D- glocosamidase (NAG) was detected, and other laboratory parameters including serum creatinine (Scr), blood urea nitrogen (BUN), 24 hour urinary protein secretion at 30d, 60d and 90d respectively. After the rats were sacrified, renal scarring and pathological changes were observed. Transforming growth factor-beta 1 (TGF-β1) of kidney was examined with RT-PCR and immunohistochemistry in the end. Results CPN rat model was successfully built based on pathological changes. Urinary NAG/Cr significantly increased at 90d in group B (P ﹤0.01 versus group A), but that of group C and D did not have such increase (P ﹤0.01 versus group B), while treatment E failed (P ﹥0.05 versus group B). Results of Scr, BUN and 24 hour urinary protein secretion in all groups didn’t show any difference during the whole study period. Severe scarring of Group C (P ﹤0.05) and D (P ﹤0.01) decreased significantly (grade 2 and 3) compared with group B. The total renal scar- ring rate also decreased in group D(P ﹤0.05). Group E didn’t show the same protective effects. Compared with group A, a significant TGF -β1 increase was observed in group B in kidney mRNA and protein level (P ﹤ 0.01 versus group A), meanwhile, that of group C and D reversed such increase (P﹤0.01 versus group B), but group E failed. Conclusions If antibiotic treatment is delayed, antibiotics combined with methylprednisone are helpful to avoid renal scarring." @default.
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- W2356225260 date "2010-01-01" @default.
- W2356225260 modified "2023-09-23" @default.
- W2356225260 title "Effects and mechanisms of Levofloxacin Lactate combined with methylprednisone on suppressing renal scarring in chronic pyelonephrits rats" @default.
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