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- W2356232803 abstract "Objective: To study the effect of GSH on oxidative stress in cultured hippocampus neurons. Methods: We founded a model of oxidative stress in hippocampal cells by adding H2O2 in cultured-medium. Four different doses of GSH were selected in the experiment. GSH was studied on this model by examination of the morphological changes of cells and the index of matrix optical density (MOD). The level of GSSG and GSH were mensurate by DTNB colorimetry. Results; The MOD index of GSH group neurons were significantly different from H2O2 group. The lower doses of GSH could rescue cells from toxic effects of hydroxyl radical generated by H2O2. while the dose of GSH raised 20mM. the effect was reduced. Conclusion: A dual response was found. GSH in lower doses may play an important role in neuroprotection. Excessive doses of GSH have no effect on the free radical damage of cultured cells." @default.
- W2356232803 created "2016-06-24" @default.
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- W2356232803 date "2005-01-01" @default.
- W2356232803 modified "2023-10-16" @default.
- W2356232803 title "Study on the effect of GSH on oxidative stress in cultured hippocampus neurons" @default.
- W2356232803 hasPublicationYear "2005" @default.
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