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- W2356249475 abstract "Aim:To observe antidepressive effects of the ethanol-extraction and water-extraction components of Valeriana officinalis L.on mice.Methods:A total of 100 mice were allocated into 10 groups,10 mice in each group.The negative control group was given normal saline at 20 mL/kg,the positive control group was given Anle tablets at 20 mg/kg,the valerian ethanol-extraction componentsⅠ,Ⅱ,Ⅲ,and Ⅳ groups were given valerian ethanol-extraction components in water,chloroform phase,ethyl acetate phase and n-buoh extraction phase at 200,5,10,and 25 mg/kg,and the valerian water-extraction componentsⅠ,Ⅱ,Ⅲ,and Ⅳ groups were given valerian water-extraction components in water,chloroform phase,ethyl acetate and n-buoh extraction phase at 200,5,10,and 25 mg/kg.All the groups were administered by gavage for 10 days.On the 10th day,the photoelectric counting method was used to record the independent activities of mice within 5 min;on the 11th day,the forced swimming time of mice within 5 min was recorded;on the 12th day,the tail suspension fixed time within 6 min was recorded.Results:There was no statistical differences for 10 groups in independent activities time(F=1.418,P=0.260),but there were statistical differences in the forced swimming time and tail suspension fixed time(F=99.670 and 106.564,P0.001),and compared with the negative control group,the forced-swimming time and tail suspension fixed time of ethanol-extraction components Ⅲ and Ⅳ groups and water extraction components Ⅲ and Ⅳ groups were shorter(P0.05).Conclusion:Ethyl acetate and n-buoh extraction phases of valerian ethanol-extraction components and water extraction components have antidepressive effects." @default.
- W2356249475 created "2016-06-24" @default.
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- W2356249475 date "2012-01-01" @default.
- W2356249475 modified "2023-09-23" @default.
- W2356249475 title "Antidepressive effects of Valeriana officinalis L.ethanol-extraction and water-extraction components on mice" @default.
- W2356249475 hasPublicationYear "2012" @default.
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