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- W2356262081 abstract "【Objective】 To investigate the effect of 18F-fluoro-deoxy-2-glucose hybrid positron emission tomography images combined CT image(18F-FDG PET/CT)on target volume delineation in patients with non-small-cell lung cancer(NSCLC).【Methods】Forty eight patients with pathological defined NSCLC underwent FDG-PET/CT simulation procedures.The gross tumor volume(GTV) was delineated by two radiation oncologists(radiation oncologist 1 and radiation oncologists 2) independently based on single CT image,integrated PET and CT image(CT-GTV1,PET-GTV1,CT-GTV2,PET-GTV2).The volume of each GTV was cumulated by Topslane treatment plan system.All the patients were treated by three-dimensional conformal radiotherapy(3DCRT) and then were followed up.【Results】PET/CT identified previously undetected distant metastatic disease in 3 patients and made them ineligible for radical conformal radiotherapy.Other 45 patients underwent completely radical conformal radiotherapy.The average of CT-GTV1 and CT-GTV2 were 179.3cm3 and 197.0cm3 respectively.There was significant difference between CT-GTV1 and CT-GTV2(P=0.026).The average of PET-GTV1 and PET-GTV2 were 161.7cm3 and 162.2cm3 respectively.There was no significant difference between PET-GTV1 and PET-GTV2(P=0.496).The GTV was decreased in 29(64.4%)patients,while increased in 16(35.6%)patients by PET/CT in radiation oncologist 1.The GTV was decreased in 33(73.3%)patients,while increased in 12(26.7%)patients by PET/CT in radiation oncologist 2.PET-GTV and CT-GTV had obviously difference proved by statistic analysis.After radiotherapy,11 patients underwent metastases,8 patients underwent local recurrent and 3 patients underwent Ⅰ~Ⅱ grade radiation pneumonitis.Local control rate was 71.1% and one-year survival rate was 66.6%.【Conclusion】 PET/CT allows accurate tumor delineation and reduces inter-observer variability.It makes delineation more easily and precisely.Precise radiotherapy to patients based on PET/CT can protect normal tissue effectively and increase local control rate." @default.
- W2356262081 created "2016-06-24" @default.
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- W2356262081 date "2007-01-01" @default.
- W2356262081 modified "2023-09-28" @default.
- W2356262081 title "Effect of ~(18)F-FDG PET/CT on Target Volume Delineation in Patients with Non-small Cell Lung Cancer (NSCLC)" @default.
- W2356262081 hasPublicationYear "2007" @default.
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