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- W2356272953 abstract "Objective To observe effects of sorafenib combined with oxaliplatin(OXA) on human hepatocellular carcinoma cell line BEL-7402.Methods In order to find the best effect,human hepatocellular carcinoma cell line BEL-7402 was treated with sorafenib and OXA alone or in combination according to different sequences.Median inhibition concentration(IC50) was calculated by MTT assay for OXA and sorafenib in BEL-7402.Altered cellular morphism and ultrastructure of the treated cells were observed under transmission electron microscope,and cell cycle distribution and altered apoptosis were analyzed by flow cytometry.Results S and G2/M phase arrest was observed in the three regimens containing OXA(OXA alone and two dosing sequences of combination),while S phase arrest was found in the regimen containing sorafenib alone.The highest apoptosis rate was(40.94±4.62)% in OXA and sorafenib combination(OXA prior used),dwarfing(30.02±4.15)% of sorafenib and OXA combination(sorafenib prior used),while it of either combination were superior to that of sorafenib alone(P0.05).Conclusion Human hepatocellular carcinoma cell BEL-7402 is highly sensitive to both sorafenib and OXA,which may cooperate in combination for synergistic inhibition on hepatocellular carcinoma cells with better effect in the dosing sequence of OXA followed by sorafenib." @default.
- W2356272953 created "2016-06-24" @default.
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- W2356272953 date "2011-01-01" @default.
- W2356272953 modified "2023-09-28" @default.
- W2356272953 title "The effect of sorafenib in combination with oxaliplatin on hepatocellular carcinoma cell line BEL-7402" @default.
- W2356272953 hasPublicationYear "2011" @default.
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