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- W2356274768 abstract "Objective:To investigate the expression of uPA and uPAR in epithelial ovarian cancer (EOC) and the relationship between uPA/uPAR and MMPs.Methods:Expression of uPA and uPAR was detected using immunohistochemical staining (SP) in EOC patients(n=100),and matched metastatec lesions (n=30) and normal ovaries tissues (n=20) from untreated patients.Co-immunolabelling of uPA/uPAR and MMP-2、MMP-9 in EOC tissues was detected using immunofluorescence staining.Results:① High expression of uPA and uPAR were observed in primary tumors and metastatic lesions in EOC,but not in normal ovarian tissues.② Over expression of uPA/uPAR in EOC was correlated significantly with progression parameters including tumor grade,relapse and ascites (P0.01),not correlated with histological type or residual tumor following surgery (P0.05).③ Co-immunolabeling of uPA/uPAR and MMP was found in EOC specimens,but not in normal ovarian tissues.Conclusion:The results indicated that uPA and uPAR play an key role in EOC progression and metastasis.The interactions of uPA/uPAR and MMPs may promote EOC growth and invasion,which suggested that uPA/uPAR as potential therapeutic targets for treating late-stage recurrent metastatic EOC." @default.
- W2356274768 created "2016-06-24" @default.
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- W2356274768 date "2010-01-01" @default.
- W2356274768 modified "2023-09-26" @default.
- W2356274768 title "Expression of uPA and uPAR in epithelial ovarian cancer and relationship between uPA/uPAR and MMPs" @default.
- W2356274768 hasPublicationYear "2010" @default.
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