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- W2356278734 abstract "Objective To investigate the relationship between the high risk alleles or genotypes of endothelial nitric oxide synthase (eNOS) polymorphism (T-786C and G894T) and the susceptibility to sepsis in Chinese Han population. Methods One hundred and seventeen septic patients were randomly selected from ICUs of 9 academic hospitals in Beijing during Apr. 2007 to May 2009. A hundred healthy volunteers were recruited as control. PCR-RFLP and PCR-SSCP were used to analyze the alleles and genotypes in eNOS T-786C and G894T polymorphisms. Results No significant difference was found in the frequency of specific allele or genotype in T-786C or G894T eNOS gene polymorphisms between septic patients and healthy volunteers in present study (P0.05). However, the frequency of genotype TC in T-786C showed an increasing trend among patients with sepsis (30.8% vs 24.0%, P=0.086). The percentage of allele C carrier was higher in patients with sepsis, but there was no significant difference between two groups (18.8% vs 12.0%, P=0.052). In addition, 4 cases of genotype CC homozygote were found in septic patients (3.4%), but no homozygote CC genotype was found in healthy volunteers. According to previous publications in corroboration with our data, it was found that a difference in genotype frequency of both eNOS T-786C and G894T polymorphisms existed in different races. Compared with Caucasian, the frequencies of genotype TC and CC in T-786C, and GT and TT in G894T were significantly lower in Asian (P=0.000). Conclusions Population with the carriage of allele C or genotype TC in T-786C eNOS gene polymorphism may have the risk of susceptibility to sepsis. Whereas, the eNOS G894T polymorphism is unlikely to be associated with the susceptibility to sepsis." @default.
- W2356278734 created "2016-06-24" @default.
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- W2356278734 date "2010-01-01" @default.
- W2356278734 modified "2023-09-27" @default.
- W2356278734 title "Relationship between eNOS T-786C,G894T polymorphisms and susceptibility to sepsis in Chinese Han population" @default.
- W2356278734 hasPublicationYear "2010" @default.
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