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- W2356291247 abstract "Objective To investigate the specific cell-mediated immune response and the therapeutic efficacy of nasal tolerance with a dual analogue (Lys262-Ala207) in the patients with myasthenia gravis (MG). Methods The numbers of mononuclear cells (MNC) expressing CD4 and/or CD25 and MNC expressing IFN-γ,IL-4 or IL-10 from peripheral blood were enumerated by flow cytometry in 39 MG patients before and after treatment with Lys262-Ala207 and in healthy controls. The clinical severity and prognosis of MG were evaluated by Xu′s clinical scoring system. Results The cells of synthesizing IFN-γ, IL-4 or IL-10 were higher before treatment and lower after treatment, whereas the numbers of CD4 +CD25 +T cells were lower before treatment and higher after treatment in group MG than in their corresponding control groups. The clinical efficiency of Lys262-Ala207 treatment was 79.48% (in 31 MG patients). Conclusions There was an activation of specific cell-mediated immunity and an imbalance of cytokines from Th1 and Th2 in MG patients. Our results might reflect the disturbance of immunological function in patients with MG. It was consistent with the characteristics of autoimmune diseases. Some immune parameters in PBMC might reflect the immune alteration in PBMC from MG patients. Nasal administration with a dual analogue Lys262-Ala207 not only suppressed function of T cell but also played an important role in the treatment of MG patients.[" @default.
- W2356291247 created "2016-06-24" @default.
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- W2356291247 date "2004-01-01" @default.
- W2356291247 modified "2023-09-23" @default.
- W2356291247 title "Analysis of relationship between specific cell-mediated immune response and therapeutic efficacy of nasal tolerance in the myasthenia gravis" @default.
- W2356291247 hasPublicationYear "2004" @default.
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