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- W2356297459 abstract "OBJECTIVE:To study the protective effects of Panax notoginseng total saponins combined with sulfuric acid against cerebral ischemia-reperfusion injury in rats. METHODS:Arteriae cerebri media ischemia-reperfusion injury model was induced. 60 SD rats were randomly divided into normal control group(constant volume of normal saline),sham operation group(constant volume of normal saline),model group(constant volume of normal saline),nimodipine group(40 mg/kg),P. notoginseng total saponins group(240 mg/kg),ethylamine sulfonic acid group(60 mg/kg),drug combination high-dose,medium-dose and low-dose groups(P. notoginseng total saponins 480,240,120 mg/kg+ethylamine sulfonic acid 120,60,30 mg/kg). They were given medicines intragastrically 1h before operation and 1h after reperfusion. The nerve defect score,cerebral infarction area,SOD activity and MDA content were determined,and the morphology of the brain was observed. RESULTS:Compared with sham operation group,neurological deficit score,cerebral infarction area and MDA content increased significantly in model group,while SOD activity decreased significantly;cerebral morphology of rats had badly damaged. Compared with model group,cerebral infarction area and MDA content decreased significantly in P. notoginseng total saponins group,ethylamine sulfonic acid group,drug combination high-dose and medium-dose groups,while SOD activity increased significantly;cerebral morphology of rats had certain improvement. Above index of drug combination high-dose and medium-dose groups were better than those of P. notoginseng total saponins group and ethylamine sulfonic acid group. CONCLUSIONS:P. notoginseng total saponins combined with ethylamine sulfonic acid can alleviate cerebral ischemia-reperfusion injury to some extent,and its mechanism may be related to reduction of nerve defect score and improvement of cerebral morphology and adjustment of biochemical indexes." @default.
- W2356297459 created "2016-06-24" @default.
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- W2356297459 date "2013-01-01" @default.
- W2356297459 modified "2023-09-25" @default.
- W2356297459 title "Protective Effects of Panax notoginseng Total Saponins Combined with Sulfuric Acid Against Cerebral Isch-emia-reperfusion Injury Model Rats" @default.
- W2356297459 hasPublicationYear "2013" @default.
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