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- W2356310426 abstract "AIM: To investigate the effect of erythromycin on the level of transforming growth factor-β1(TGF-β1) and γ-glutaglutamylcysteine synthetase(γ-GCS) in smoking rats,and to explore the antioxidate therapeutic role of erythromycin in chronic obstructive pulmonary disease.METHODS: Wistar rats were exposed to cigarettes smoking to establish the model.After passive smoking for 4 weeks,erythromycin intragastric intervention was administered continuously for 8 weeks.The expiratory airway resistance and lung compliance were assessed and the expression levels of TGF-β1 and γ-GCS proteins(and the mRNA) in airway endothelial cells and alveolar macrophages were observed respectively by immunohistochemical,immunocytochemical and(in situ) hybridization.RESULTS: The expiratory airway resistance was increased and the lung compliance was degraded significantly in smoking group and erythromycin group,compared to control group.In erythromycin group,the airway resistance was lower and the lung compliance was higher than that in smoking group(P0.05).The levels of TGF-β1 and γ-GCS in smoking group and erythromycin group was obviously increased in airway endothelial cells and alveolar macrophages in comparison with control group(P0.05).The levels of TGF-β1 and γ-GCS were inhibited by erythromycin(P0.05).TGF-β1 was obviously positive correlated with γ-GCS in smoking group,but this was not found in erythromycin group.CONCLUSION: Erythromycin therapy improves pulmonary function and relieves emphysema change induced by smoking in rats,and decreases the expression of TGF-β1 and γ-GCS in alveolar macrophages and airway endothelial cells,suggesting that erythromycin may play a role in the antioxidate therapeutic in COPD." @default.
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- W2356310426 date "2008-01-01" @default.
- W2356310426 modified "2023-09-23" @default.
- W2356310426 title "Effect of erythromycin on transforming growth factor-β_1 and γ-glutamylcysteine synthetase in lung of smoking rats" @default.
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