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- W2356315117 abstract "Objective To study the expression levels of squamous cell carcinoma antigen(SCCA),cytokeration 19 fragment 21-1(CYFRA21-1) and tissue polypeptide specific antigen(TPS) in squamous cell cervical cancer(SCC),and analyze their clinical significance in monitoring chemotherapy effect.Methods The levels of serum SCCA,CYFRA21-1 and TPS were determined by ELISA in 31 SCC patients and 30 health women.The levels of serum SCCA,CYFRA21-1 and TPS are compared between pre-and post-chemotherapy in patients of SCC.Results ①The levels of serum SCCA,CYFRA21-1 and TPS in SCC were significantly higher than those of normal group(P0.01).The specificities of SCCA,CYFRA21-1 and TPS in diagnosing SCC were all 100%.The sensitivities of SCCA,CYFRA21-1 and TPS were 70.00%,48.00% and 86.21%,respectively.The level of TPS was significantly higher than that of SCCA and CYFRA21-1(P0.05).The sensitivities of SCCA plus TPS and three markers was 96.43% and 95.83%,respectively.②There was no difference of SCCA level at different clinical stages(P0.05).SCCA level was significantly higher in moderate and high differential carcinoma than that in low differential cancer(P0.05),but there was no statistical significance between moderate and high differential carcinoma,and lymph node metastasis.The levels of CYFRA21-1 and TPS at stage Ⅲ plus Ⅳ was significantly higher than that at stage ⅠplusⅡ(P0.05),but there was no statistical significance among the different differentiated cancer.TPS level,but not the CYFRA21-1 level showed significant difference in lymph node metastasis(P0.05).③At post-chemotherapy,the levels of SCCA and TPS were decreased significantly than those of pre-chemotherapy in the CR and PR(P0.05),but CYFRA21-1 level did not show the same change.The levels of SCCA,CYFRA21-1 and TPS did not show significant differences between post-and pre-chemotherapy in the SD or PD.Conclusion The serum levels of SCCA,CYFRA21-1 and TPS show a clinical significance in SCC and can be used to chemotherapy efficiency in patients with SCC." @default.
- W2356315117 created "2016-06-24" @default.
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- W2356315117 date "2011-01-01" @default.
- W2356315117 modified "2023-09-28" @default.
- W2356315117 title "Serum levels of SCCA,CYFRA21-1 and TPS in patients with squamous cell cervical cancer and yheir value for monitoring chemotherapy effect of treating squamous cell cervical cancer" @default.
- W2356315117 hasPublicationYear "2011" @default.
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