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- W2356323437 abstract "Objective To probe the function of matrix metalloproteinase 2(MMP 2) and matrix metalloproteinase 9(MMP 9) in primary human brain gliomas invasion. Methods The expression of MMP 2 and MMP 9 in glioma and brain metastases tissues was studied via the immunohistochemical stain.At the same time,the expression rate was compared with peritumoral low|density range seen on CT|scan. Results 1. In primary gliomas,the expression of MMP 2 and MMP 9 was positive in 35^5%(16/45) and 62^2%(28/45) of cases respectively.In high malignant glioma the positive rate (56^5%) of MMP 2 is significantly lower than that (91^3%) of MMP 9. 2. Peritumoral low|density range seen on CT|scan was correlated with the positive expression of MMP 2 and MMP 9 ( P0^01 ) and with the expression rate of MMP|9( P 0^01),but not with that of MMP|2( P0^05). 3. In brain metastases the overexpression of MMP|2 is not statistically different from that of MMP|9( P0^05). The overexpression rate of both MMP|2 and MMP|9 in high malignant gliomas as compared with brain metastases is not statistically different( P0^05). Conclusion MMP|2 and MMP|9 may serve as indicators of invasion and malignant phenotype.Neither of them can represent the phenotype of metastasis,but both can represent that of matrix degradation.Moreover,MMP|9 may play more important role in glioma invasion than does MMP|2." @default.
- W2356323437 created "2016-06-24" @default.
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- W2356323437 date "2001-01-01" @default.
- W2356323437 modified "2023-09-25" @default.
- W2356323437 title "THE FUNCTION OF MMP-2 AND MMP-9 IN PRIMARY HUMAN BRAIN GLIOMAS INVASION" @default.
- W2356323437 hasPublicationYear "2001" @default.
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