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- W2356332941 abstract "Objective:To study the role of matrix metalloproteiases (MMPs) and vascular endothelial growth factor (VEGF) in the invasion and metastases of laryngeal cancer. Methods: The expressions of MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-10 and VEGF were examined by immunohistochemical technique in carcinoma tissues and para-tumorous tissues of 70 laryngeal cancer patients. The results and clinicopathologic data were analyzed by statistics, and the relationships between expression of MMPs and VEGF were also observed. Result The expression of MMPs and VEGF were significantly higher in carcinoma tissues than that in para-tumorous tissues. The expression of MMP-1, MMP-2, MMP-7, MMP-9, MMP-10 and VEGF had a close relationship with invasive depth (T grades) and had no obvious relationship with pathological grade and primary location. The expression of MMP-2、MMP-7, MMP-9 and VEGF were correlated to neck nodal metastases. Conclusion: MMP-2, MMP-7, MMP-9 and VEGF may act as sensitive makers in estimating progression of laryngeal cancer. Using inhibitors of MMPs and VEGF may suppress the invasion and metastases of tumor and become a new way to therapy cancer." @default.
- W2356332941 created "2016-06-24" @default.
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- W2356332941 date "2008-01-01" @default.
- W2356332941 modified "2023-09-26" @default.
- W2356332941 title "The Correlative Investigation of Matrix Metalloproteiases and Vascular Endothelial Growth Factor with the Invasion and Metastases in Laryngeal Cancer" @default.
- W2356332941 hasPublicationYear "2008" @default.
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