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- W2356352012 abstract "Objective To detect the expression of Smad2 and Smad7 in cutaneous squamous cell carcinomas(SCC) and normal squamous epithelia of skins,analyze the relationship of two Smad expressions in SCC of differentiation grades and clinical stages,thus explore the role of Smad2 and Smad7 in the pathogenesis of SCC.Methods Paraffin-embedded tissue sections containing normal squamous epithelia,well differentiated,moderately differentiated and poorly differentiated SCC were stained by SABC immunohistochemistry technique to detect the expression and location of Smad2 and Smad7.Protein immunoexpression was quantified by image analysis in the context of histopathological parameters.The different expressions of Smad2 and Smad7 among all the tissue sections were compared.Expression of Smad2 and Smad7 in different clinical stages of SCC was also analyzed. Results Expression of Smad2 and Smad7 located in cytoplasm in normal squamous epithelia and SCC of skins.There was statistically significant difference of Smad2 and Smad7 expression between normal skin and SCC(P0.05).Compared with normal group,expression of Smad2 was down-regulated and Smad7 was up-regulated in SCC. Obvious difference of expression of Smad2 demonstrated in stage Ⅰ or Ⅱ compared with stage Ⅲ(P0.05).However,there was no statistic difference of Smad7 though gradually increasing from stage I to stage Ⅲ. Conclusions Down-regulation of Smad2 and up-regulation of Smad7 contribute to relieve the inhibition effect mediated by TGF β of cellular proliferation,which results in losing of cell growth suppression mediated by TGF β and contribute to tumor development or progression.Down-regulation of expression of Smad2,down-stream molecular of TGF β signaling pathway,was associated with invasion and metastasis of SCC." @default.
- W2356352012 created "2016-06-24" @default.
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- W2356352012 date "2005-01-01" @default.
- W2356352012 modified "2023-09-24" @default.
- W2356352012 title "Expression of Smad2 and Smad7 Proteins in Cutaneous Squamous Cell Carcinomas and its Clinical Significance" @default.
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