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- W2356354802 abstract "Objective To evaluate the effect of combined therapy of temozolomide and Bcl-2 siRNA on growth inhibition of human glioblastoma U251 cells.Methods U251 cells were transfected with Bcl-2 siRNA via LipofectaminTM2000,while temozolomide was added into U251 cells medium.The silent effect on Bcl-2 gene expression was evaluated via Western blot at 24 h after transfection.The proliferation,apoptosis and membrane potential of mitochondrion of U251 cells were evaluated after temozolomide treatment.ResultsBcl-2 siRNA can specifically suppress the expression of Bcl-2 gene of U251 cells.Combined therapy of temozolomide and Bcl-2 siRNA inhibited proliferation,induced apoptosis,and reduced membrane potential of mitochondrion of U251 cells(P0.05).Conclusion Temozolomide and Bcl-2 siRNA combination therapy could effectively improve the sensitivity of U251 cells to temozolomide via the membrane potential change of mitochondrion of the glioblastoma cells." @default.
- W2356354802 created "2016-06-24" @default.
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- W2356354802 date "2008-01-01" @default.
- W2356354802 modified "2023-09-23" @default.
- W2356354802 title "Effects of temozolomide and Bcl-2 siRNA combination therapy on growth of human glioblastoma U251 cells" @default.
- W2356354802 hasPublicationYear "2008" @default.
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