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- W2356359097 abstract "Objective To investigate the expression of CRF、UCN1、CRFR1in IBS rat model and to study the role in the mechanism of IBS.Methods Twenty-four male rats were divided into four gruops:normal control,wrap restraint stress only,chronic unpredictable mild sress(CUMS)only and CUMS plus wrap restraint.All of groups were evaluated by weight changes,fecal granules,consumption of sucrose solutions and open-field test.The changes of CRF、UCN1 and CRFR1 mRNA expression in colon of rats were detected by real time RT-PCR.Results These model rats presented typical visceral hypersensitivity of IBS.The real time RT-PCR method showed the expression of CRF、UCN1 and CRFR1 decreased in all stress groups(P0.01) compared with control group.Conclusion CRF、UCN1 and CRFR1 are related to colon functional changes induced by sress." @default.
- W2356359097 created "2016-06-24" @default.
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- W2356359097 date "2012-01-01" @default.
- W2356359097 modified "2023-09-27" @default.
- W2356359097 title "The Expression of CRF、UCN1 and CRFR1 in the Colon of Irritable Bowel Syndrome Model Rat" @default.
- W2356359097 hasPublicationYear "2012" @default.
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