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- W2356364073 abstract "Objective:To determine the expression of lysyl oxidase(LOX) in subjects with pelvic organ prolapse as compared to asymptomatic controls,to explore whether the alteration in LOX expression could contributed to pelvic organ prolapse (POP) and analysis the relationship between LOX and etiology of POP.Method:Transvaginal biopsies were obtained from the anterior vaginal in POP and in comparable control.Forty- six women participated in the study and they were divided into 3 groups. Western blotting study was performed to verify the protein level of LOX in anterior vaginal wall,GAPDH was used as the reference for the semiquatitative analysis.Results:The expression of LOX was significantly reduced(p0.05) in both premenopausal (44%) and postmenopausal(82%) patients with POP,compared to the control group.The mean concentration of LOX was 44%lower in the premenopausal women with POP,In POP and control group,the expression of LOX was positively correlated with parity;In POP group,the expression of LOX was positively correlated with age、menopause status and BMI.Conclusion:①Patients with severe pelvic organ prolapse have a significant decreased level of LOX in the anterior vaginal wall,which maybe significantly reduce the content of collagen and alter the structure of collagen.These alterations could result in a less flexible connective tissue and these tissues probably were more likely to break,which suggested that LOX might be involved in the pathogenesis of POP.②The negative correlation with age、menopausal status and BMI in POP group indicated decrease in cross-link of collagen in genital tract relaxed the pelvic floor and disposed POP to progress." @default.
- W2356364073 created "2016-06-24" @default.
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- W2356364073 date "2008-01-01" @default.
- W2356364073 modified "2023-09-27" @default.
- W2356364073 title "Expression and clinical significance of lysyl oxidase on pelvic organ prolapse" @default.
- W2356364073 hasPublicationYear "2008" @default.
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