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- W2356369535 abstract "Objective To investigate upper gastrointestinal bleeding induced by aspirin (ASA) in primary or secondary prevention of coronary artery disease . Methods Patients with defined coronary artery disease or hypertension from 1992 to 2000 were divided into 3 groups. Those with coronary disease or hypertension accompanied by at least one cardiovascular risks were enrolled in Group A. No gastric or duodenal ulcer had been found in this group and the patients took ASA 50～100 mg/d. Those with peptic ulcer were enrolled in Group B. And hypertensive patients without cardiovascular risks were enrolled in Group C, in which ASA was not administrated. All the patients were followed up 1～8 years. The end point was event of upper gastrointestinal bleeding. Results 13 cases of upper gastrointestinal bleeding were observed in 593 patients of Group A followed up for 5 932 person·year. in total. Incidence was 2 19/kiloperson·year. 3 cases occurred in Group B with 72 patients followed up for 731 person·year, and incidence was 4 1/kiloperson·year. 1 case was recorded in 87 patients of Group C followed up for 1 023 person·year and incidence was 0 98/kiloperson·year. The difference of incidence in 3 groups was no statistically signi ficant ( P 0 05). Incidence of upper gastrointestinal bleeding in front of 4 years were 8 4%, 8 8%, 0 58% and 0 38% and come after 4 years for average 0 24% in Group A. Compared with Group C, the difference was significant in the first year ( χ 2 =5 5, P0 025 ). Conclusions Incidence of upper gastrointestinal bleeding was 2 19/kiloperson·year in patients taking low-dose ASA for primary or secondary prevention of coronary artery disease, the differenceis no statistically significant compared with the non-taking group. The incidence of taking ASA group was relatively high in the first two years, and only the difference of the first year is statistically significant. So low-dose ASA can be safely used in these patient." @default.
- W2356369535 created "2016-06-24" @default.
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- W2356369535 date "2002-01-01" @default.
- W2356369535 modified "2023-09-23" @default.
- W2356369535 title "Upper gastrointestinal bleeding induced by low-dose aspirin in prevention of coronary disease" @default.
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