Matches in SemOpenAlex for { <https://semopenalex.org/work/W2356371323> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2356371323 abstract "Objective To observe the inhibition effect of cinobufacini on human cholangiocarcinoma in vivo and in vitro. Methods Cells w ere cultivated in vitro,and divided into negative control group and cinobufacini six doses groups randomly after 24 h. MTT assay w as used to evaluate the effect of cinobufacini on proliferation in QBC939 cells in three phase respectively. After subcutaneous implantation of the QBC939 cells,the tumor-bearing nude mice w ere randomized into control group,5-Fu group,cinobufacini three doses groups. The medication groups w ere given the corresponding drugs intraperitoneally. General activities and food intake of nude mice w ere observed daily. After 12-day treatment,nude mice w ere sacrificed,the tumor w as w eighed and the inhibition rate w as calculated. The expression of TNF-α,IL-6 and sVCAM-1 of serum w ere determined by ELISA assay. Results Six doses of cinobufacini inhibited the proliferation of QBC939 cells,it had a significant difference compared w ith the control group,and w ith dose and time increased,the inhibition rate increased. Cinobufotalin intraperitoneal injection improved the general condition of the activities in nude mice,increased the food intake,and inhibited the tumor grow th of tumor-bearing nude mice,it had a significant difference compared w ith the control group. Cinobufotalin improved the level of TNF-α,decreased the level of IL-6 and sVCAM-1. Conclusion Cinobufacini can inhibit proliferation of QBC939 cells in vitro and in vivo,its antitumor effect in vivo involved regulating the levels of TNF-α,IL-6 and sVCAM-1." @default.
- W2356371323 created "2016-06-24" @default.
- W2356371323 creator A5021342930 @default.
- W2356371323 date "2014-01-01" @default.
- W2356371323 modified "2023-09-28" @default.
- W2356371323 title "Anti-tumor effect of cinobufacini on human cholangiocarcinoma cells" @default.
- W2356371323 hasPublicationYear "2014" @default.
- W2356371323 type Work @default.
- W2356371323 sameAs 2356371323 @default.
- W2356371323 citedByCount "0" @default.
- W2356371323 crossrefType "journal-article" @default.
- W2356371323 hasAuthorship W2356371323A5021342930 @default.
- W2356371323 hasConcept C126322002 @default.
- W2356371323 hasConcept C150903083 @default.
- W2356371323 hasConcept C16685009 @default.
- W2356371323 hasConcept C17991360 @default.
- W2356371323 hasConcept C185592680 @default.
- W2356371323 hasConcept C202751555 @default.
- W2356371323 hasConcept C207001950 @default.
- W2356371323 hasConcept C2780159080 @default.
- W2356371323 hasConcept C2780783641 @default.
- W2356371323 hasConcept C55493867 @default.
- W2356371323 hasConcept C71924100 @default.
- W2356371323 hasConcept C86803240 @default.
- W2356371323 hasConcept C98274493 @default.
- W2356371323 hasConceptScore W2356371323C126322002 @default.
- W2356371323 hasConceptScore W2356371323C150903083 @default.
- W2356371323 hasConceptScore W2356371323C16685009 @default.
- W2356371323 hasConceptScore W2356371323C17991360 @default.
- W2356371323 hasConceptScore W2356371323C185592680 @default.
- W2356371323 hasConceptScore W2356371323C202751555 @default.
- W2356371323 hasConceptScore W2356371323C207001950 @default.
- W2356371323 hasConceptScore W2356371323C2780159080 @default.
- W2356371323 hasConceptScore W2356371323C2780783641 @default.
- W2356371323 hasConceptScore W2356371323C55493867 @default.
- W2356371323 hasConceptScore W2356371323C71924100 @default.
- W2356371323 hasConceptScore W2356371323C86803240 @default.
- W2356371323 hasConceptScore W2356371323C98274493 @default.
- W2356371323 hasLocation W23563713231 @default.
- W2356371323 hasOpenAccess W2356371323 @default.
- W2356371323 hasPrimaryLocation W23563713231 @default.
- W2356371323 hasRelatedWork W2008187359 @default.
- W2356371323 hasRelatedWork W2351000273 @default.
- W2356371323 hasRelatedWork W2352877250 @default.
- W2356371323 hasRelatedWork W2354189070 @default.
- W2356371323 hasRelatedWork W2356481950 @default.
- W2356371323 hasRelatedWork W2357355043 @default.
- W2356371323 hasRelatedWork W2359107428 @default.
- W2356371323 hasRelatedWork W2361496678 @default.
- W2356371323 hasRelatedWork W2362923964 @default.
- W2356371323 hasRelatedWork W2366271449 @default.
- W2356371323 hasRelatedWork W2369071974 @default.
- W2356371323 hasRelatedWork W2373660558 @default.
- W2356371323 hasRelatedWork W2381325625 @default.
- W2356371323 hasRelatedWork W2386301372 @default.
- W2356371323 hasRelatedWork W2389631441 @default.
- W2356371323 hasRelatedWork W2389789178 @default.
- W2356371323 hasRelatedWork W2390675486 @default.
- W2356371323 hasRelatedWork W2391800960 @default.
- W2356371323 hasRelatedWork W2392685597 @default.
- W2356371323 hasRelatedWork W2415721580 @default.
- W2356371323 isParatext "false" @default.
- W2356371323 isRetracted "false" @default.
- W2356371323 magId "2356371323" @default.
- W2356371323 workType "article" @default.