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- W2356376048 abstract "AIM: To investigate homeodomain-interacting protein kinase 2(HIPK2) gene expression level and its clinical significance in acute leukemia(AL) patients.METHODS: HIPK2 mRNA was determined by semi-quantitative reverse transcriptase polymerase chain reaction(semi-quantitive RT-PCR) in patients with acute leukemia and healthy donors.The relative transcription level was compared between the study group and the control group.RESULTS: ① The relative expression level of HIPK2 mRNA in AL patients was 0.364±0.286,significantly lower than that in control(1.160±0.272,P0.01).② HIPK2 gene expression level in M2b type was significantly higher than that in other acute myeloid leukemia(AML) subtypes(P0.05).③ HIPK2 gene expression in AL,except M2b,had no relationship with the clinical prognostic factors such as cytogenetic or molecular aberrations,WBC counts,LDH, mdr1,P170 protein and age(P0.05).CONCLUSION: AL has significantly lower HIPK2 mRNA expression as compared to normal control,which may be associated with leukemogenesis and/or disease progression of AL." @default.
- W2356376048 created "2016-06-24" @default.
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- W2356376048 date "2006-01-01" @default.
- W2356376048 modified "2023-09-28" @default.
- W2356376048 title "HIPK2 gene expression and its clinical significance in acute leukemia" @default.
- W2356376048 hasPublicationYear "2006" @default.
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