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- W2356396768 abstract "Objective To investigate the effect of different regime of alendronate(ALN) on the serum assays and bone mineral density(BMD) in osteoporosis(OP) rats,and to compare the difference between the two regime and to provide pharmacologic evidence for the better therapeutic choice.Methods Rat models of OP were induced by retinoic acid.The one regime was to give ALN by intragastric one times per day(equivalent dose of 10 mg daily for people) for 28 d.Another regime was to give ALN by intragastric once a week(equivalent dose of 70 mg once weekly for people) for 28 d.The levels of serum calcium,phosphorus,alkaline phosphatase(ALP) and interleukin(IL-6) were observed.The BMD of the rats was calculated by weight/volume.Results Different regime of alendronate significantly decreased the serum level of calcium,ALP and IL-6,increased serum phosphorus and BMD of OP rats.However,there were no significant difference between the two drug regime in the treatment in the OP rat.Conclusion The two regime of ALN could enhance the serum assays of OP rats.There was no significant difference between the once-daily and once-weekly regimen of ALN." @default.
- W2356396768 created "2016-06-24" @default.
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- W2356396768 date "2010-01-01" @default.
- W2356396768 modified "2023-09-27" @default.
- W2356396768 title "Effect of Different Regime of Alendronate on the Serum Assays and Bone Mineral Density in Osteoporosis Rats" @default.
- W2356396768 hasPublicationYear "2010" @default.
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