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- W2356437112 abstract "Objective To identify the neural mechanisms of impulsivity and the response inhibition deficits of the chroin heroin users using event-related functional MRI(stop-signal task).Methods Seventeen individuals with heroin dependence and 17 healthy control subjects underwent fMRI scan while executing stop-signal task after anatomical scanning in 3.0 T scanner.The AFNI package was used for fMRI data preprocessing and statistical analysis.Results The behavioral data showed that the stop signal reaction rime(SSRT) of heroin users was significantly longer than that of the control group.There was no significant difference in activation of the primary motor cortex and supplementary motor area between two groups.Comparing to the control group,heroin users had weaker activation in the right dorsal lateral prefrontal cortex,right inferior prefrontal cortex,and anterior cingulated cortex,but stronger activation in bilateral striatum and amygdala while behavioral inhibition needed.Conclusion The results suggest that heroin users have significant changes within impulsivity and inhibitory network,where the right prefrontal cortex is considered as main region for inhibition,while the anterior cingulated cortex is associated with error monitoring,and the amygdale controls impulsivity and emotion." @default.
- W2356437112 created "2016-06-24" @default.
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- W2356437112 date "2011-01-01" @default.
- W2356437112 modified "2023-09-25" @default.
- W2356437112 title "The BOLD-fMRI study of behavior inhibition in chronic heroin addicts" @default.
- W2356437112 hasPublicationYear "2011" @default.
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