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- W2356451079 abstract "OBJECTIVE To investigate the clinical significance of distribution of the human papilloma virus(HPV) subtypes in high grade cervical intraepithelial neoplasia and cervical cancer.METHODS A total of 237 cases of high grade cervical intraepithelial neoplasia(CIN Ⅱ,Ⅲ) patients and 22 cases of cervical cancer patients were detected for HPV DNA subtypes by using PCR in vitro amplification and DNA reverse dot blot.RESULTS Of totally 259 cases with severe CIN and cervical cancer,a total of 247 cases with HPV infections were detected with the total positive rate of 95.37%;of 237 cases with CIN Ⅱ and CIN Ⅲ,there were 228 cases with HPV tested positive,the positive rate was 96.20%;of the 22 cases with cervical cancer,there were 19 cases with the HPV tested positive,the positive rate was 86.36%,the difference was not statistically significant;of 228 cases of severe CIN Ⅱand CIN Ⅲ women with HPV tested positive,there were 209 cases with single type of HPV infection and 19 cases with multiple types of HPV infections;of the 19 cases with cervical caner,all of them were with single type of HPV infection,the difference between the two was not statistically significant;of all the cases with single type of HPV infection,there were 124(54.39%) cases with HPV16 infections and 44(19.30%) cases with HPV58 infection;the difference in the distribution of the subtypes in the cases with CINⅡ,Ⅲ and the cases with cervical cancer was not statistically significant.CONCLUSION HPV infection is very common in women with CIN Ⅱ,Ⅲ and cervical cancer.The persistent infection of HPV 16 is a very important event in the pathogenesis of cervical cancer." @default.
- W2356451079 created "2016-06-24" @default.
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- W2356451079 date "2013-01-01" @default.
- W2356451079 modified "2023-09-23" @default.
- W2356451079 title "Clinical significance of distribution of human papilloma virus in high grade cervical intraepithelial neoplasia and cervical cancer" @default.
- W2356451079 hasPublicationYear "2013" @default.
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