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- W2356454793 abstract "StAR is believed to be the key regulator of steroid hormone biosynthesis. Transient transfection of both steroidogenic and nonsteroidogenic cells with StAR complementary DNA (cDNA) directly stimulated steroid production in the absence of trophic hormone stimulation. De novo synthesis of StAR protein is required for intramitochondrial translocation of cholesterol, the substrate of steroid biosynthesis, to the cytochrome P450 side chain cleavage enzyme, which is located on the matrix side of the inner mitochondrial membrane. Transfer of cholesterol into the inner mitochondrial membrane is carried out during importation and processing of StAR protein in the mitochondrial. Using the model of pregnant mare serum gonadotropin (PMSG) primed rat ovary, we studied the expression of mRNA for steroidogenic acute regulatory protein (StAR) in developmental and atretic follicles. The follicular physiological status was evaluated by in situ 3′ end labeling (TUNEL) and morphological changes. The results show that StAR mRNA is expressed in theca interstitial cells and luteinized granulosa cells, but not in oocyte. Expression of StAR mRNA in the theca interstitial cells was observed at 12 hours, increased at 24 hours, and reached the maximum at 72 hours after PMSG injection. Advanced atresia occurred in most of the unovulated follicles at 96 hours after PMSG treatment, while the expression of StAR mRNA disappeared. However, StAR mRNA was still expressed in the follicles at early stage of atresia and no obvious difference was observed compared with those in healthy follicles. These results indicate that expression of StAR mRNA is in accordance with synthesis of the steroid hormones in rat ovary and its expression is not influenced at the early stage of atresia." @default.
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- W2356454793 date "2000-01-01" @default.
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- W2356454793 title "Expression of mRNA for steroidogenic acute regulatory protein in rat developmental and atretic follicles" @default.
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