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- W2356456657 abstract "Objective Study the efficacy and safety of epristeride, a new uncompetitive 5α-reductase inhibitor, in the treatment of benign prostatic hyperplasia(BPH). Methods A multicentral opened clinical trial was conducted. 2 006 BPH patients were enrolled in the trial, in which 5mg epristeride was orally administered twice a day. Results After 4 months therapy, IPSS score was averagely decreased 6.12(28.8%) ( P 0.0001); maximum urinary flow rate was averagely increased 3.48 ml/s(33.4%) ( P 0.0001); prostatic volume was averagely decreased 4.91 ml(11.6%) ( P 0.0001 ); residual urinary volume was averagely decreased 19.1 ml(38.4%) ( P 0.0001 ). The total effective rate was 83.4%. The clinical adverse rate was 6.63%, and most of adverse reaction were mild and moderate. The laboratory abnormity rate was 2.49%. Conclusions Epristeride, as a new 5α-reductase inhibitor, for the treatment of BPH, is effective and safe to improve the subjective symptom and objective data of the patients." @default.
- W2356456657 created "2016-06-24" @default.
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- W2356456657 date "2002-01-01" @default.
- W2356456657 modified "2023-09-25" @default.
- W2356456657 title "Phase IV study with epristeride,a new type of 5α-reductase inhibitor,on treatment of benign prostatic hyperplasia" @default.
- W2356456657 hasPublicationYear "2002" @default.
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