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- W2356458325 abstract "Objective To study the effects of c9,t11-conjugated linol eic acid on the killing ability of macrophage to B16-MB cells in C57 mice and ex plore its possible mechanism. Methods Five levels of CLA was designed as 0,25,50,75,100 ?μmol/L.After macrophage was treated with CLA for 24?h,the MTT assay was used to evaluate the killing ability of macrophage to B16-MB cells;the RT-PCR was us ed to detect the expression of macrophage cytokine IL-6,TNF-a and iNOS mRNA in C 57 mice.Results At the concentrations of 100,75?μmol/L c9,t11-C LA,the cytotoxic effects of macrophage on tumor cells were 18% and 14.5%,respect iely.At the same time,the expression of IL-6,TNF-α and iNOS mRNA increased. Conclusion c9,t11-CLA could increase the killing ability of macrophage to B16-MB cells in mice,and was associated with the induction of I L-6,TNF-α and iNOS mRNA expression.Antitumor ability of CLA may be associated w ith taking part in immune regulation action." @default.
- W2356458325 created "2016-06-24" @default.
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- W2356458325 date "2003-01-01" @default.
- W2356458325 modified "2023-09-23" @default.
- W2356458325 title "Effects of c9,t11-conjugated linoleic acid on cytokine expression of macrophage" @default.
- W2356458325 hasPublicationYear "2003" @default.
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