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- W2356466386 abstract "Objective To observe the effects of nonylphenol on inhibin and androgen binding protein(ABP) expressions in the testis of rats.Method 36 rats (19 day aged) were divided randomly into 4 groups. 0, 11,44 and 176 mg/kg of nonylphenol(NP) were given by intraperitoneal injection in each group respectively. And then 3 rats were sacrificed after 6, 24, and 48 hours in each groups respectively. Abstracted the total RNA from testes and quantified the mRNA of inhibin and ABP in each group by RT-PCR.Results The ABP expressions decreased with the increasing given NP, and there was a dose-effect relationship. Compared with control group, the decreases of ABP in 11,44,176 mg/kg groups were significant (P0.01) after 6 hours,. in 44 and 176 mg/kg groups were significant after 24hours (P0.05 or P0.01), and only in 176 group were significant after 48 hours. The expressions of inhibin were decreased in 44 and 176mg/kg groups respectively (P0.01) after 24 and 48 hours.Conclusions NP could decrease the expressions of ABP in Sertoli cells of rats. At lower dose, NP might not affect the expressions of inhibin in Sertoli cells, but at a higher dose, it might decrease its expression." @default.
- W2356466386 created "2016-06-24" @default.
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- W2356466386 date "2002-01-01" @default.
- W2356466386 modified "2023-09-25" @default.
- W2356466386 title "The effects of nonylphenol on inhibin and androgen binding protein expressions in the testis of rats" @default.
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