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- W2356485271 abstract "Objective To study anticoagulation effects of Phospholipid-binding anticoagulation protein(PBAP) from Agkistrodon halys Brevicaudus Venom.Methods The activated partial thromboplastin time(APTT),Prothrombin time(PT),Fibrinogen(FIB),Thrombin time(TT) and Factor activity were determined by kit illustration.The TTI test was peformed according to the method of Schleider.The dRVVT test was done in quadruplicate using commercial kits acoording to the manufacturer's iustrution.Results Comored with conred group,the Phospholipid-binding anticoagulation protein(PBAP) from Agkistrodon halys Brevicaudus Venom could markedly prolong APTT and DRVVT(P0.01) concentration-dependent but time-independent manner,accentuate the inhibitor effect of TTⅠby decreasing phospholipid concentration.and inhibit the activities of FⅧ:C,FⅨ:C,FⅪ:C,FⅫ:C.Conclusion The Phospholipid-binding anticoagulation protein from the Agkistrodon halys Brevicaudus Venom can anticoagulate and inhibit FⅧ:C,FⅨ:C,FⅪ:C,FⅫ:C activity and bind Phospholipid." @default.
- W2356485271 created "2016-06-24" @default.
- W2356485271 creator A5004801782 @default.
- W2356485271 date "2008-01-01" @default.
- W2356485271 modified "2023-09-28" @default.
- W2356485271 title "Anticoagulant Effects of Phospholipid-binding Anticoagulants Protein from Agkistrodon Halys Brevicaudus Both in vitro on Human Plasma and in Vivo on Rabbits" @default.
- W2356485271 hasPublicationYear "2008" @default.
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