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- W2356494697 abstract "Objective:To investigate the inhibitory effect of cisplatin combined with adenovirus-mediated Runx3(Ad-Runx3) on the growth of transplanted H22 hepatocarcinoma in mice and its regulatory mechanism.Methods:The mice inoculated with H22 cells were divided into 4 groups at random: control group,Ad-Runx3 group,cisplatin group and combination group(cisplatin plus Ad-Runx3).Fifteen days later,the mice were killed,then the weight of H22xenograft tumor was measured and the tumor-inhibiting rate was calculated.Transmission electron microscopy(TEM) was used to observe the ultramicro-structure alterations of H22xenograft tumor tissue in BALB/c mice.Results:The inhibitory activity was the strongest in combination group,with the inhibition rate reaching 65.7%.TEM demonstrated the existence of apoptotic cells and apoptotic bodies in H22xenograft tumor tissue in combination group.Conclusion:Combination of cisplatin and Ad-Runx3 exerts strong inhibitory activity on the growth of transplanted H22hepatocarcinoma in mice.The effect may be correlated to the inducement of cellular apoptosis of transplanted hepatocarcinoma in mice." @default.
- W2356494697 created "2016-06-24" @default.
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- W2356494697 date "2011-01-01" @default.
- W2356494697 modified "2023-09-24" @default.
- W2356494697 title "Research on Inhibitory Effect of Adenovirus-Mediated Runx3 Gene Combined with Cisplatin in Treatment of Mice Bearing Transplanted Hepatocarcinoma" @default.
- W2356494697 hasPublicationYear "2011" @default.
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