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- W2356504170 abstract "Objective:The keratocyte' s abnormal proliferation plays an important role in haze formation after refractive operation,including photorefractive keratectomy(PRK),LASEK and Epi-LASIK.In this study,we plan to explore the antiproliferative effect about tet and clear out the extent of the effect,which one is more important,antiproliferation or apoptosis.Methods:The primary cultured and subcultured keratocytes from NewZealand white rabbits were exposed to different concentrations of tetrandrine(2μg/ml,3μg/ml,4μg/ml)in experimental groups and the culture medium containing 20μl PBS in contrast group.We detect the expression of PCNA by immunocytochemistry,observe the cell cycle and ratio of apoptosis by FCM.Results:The immunocytochemistry showed that with the treatment of tetrandrine,48 hours later,the expression of PCNA depressed with the concentrations of tetrandrine' s increasing,and the index of proliferation also deprssed.FCM result showed that the cell cycle was blocked at GO/G1 phase,the cells at G1 phase multed with the concentrations of tetrandrine' s increasing and the index of apoptosis multed too.The slope rate of the curve about index of proliferation larger than slope rate of the curve about index of apoptosis.Conclusion:Tetrandrine obversly depressed the expression of PCNA,and blocked cells at GO/G1 phase to antiproliferat.And at the concentrations of tetrandrine(2μg/ml,3μg/ml,4μg/ml),the main action of Tet was not apoptosis but antiproliferative." @default.
- W2356504170 created "2016-06-24" @default.
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- W2356504170 date "2009-01-01" @default.
- W2356504170 modified "2023-09-24" @default.
- W2356504170 title "An investigation about antiproliferative effect of tetrandrine on keratocyte" @default.
- W2356504170 hasPublicationYear "2009" @default.
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