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- W2356509823 abstract "Objective:To observe the microvessel density(MVD) and histomorphological change in the development of induced rat breast cancer.Methods: Eighty-five female Wistar rats and twenty-two female SD rats were administrated intragastrically with 10 mg/ml 7,12-dimethyl-1,2-benzanthracene(DMBA) sesame oil solution.Seventeen rats died within 8 weeks.The remaining 90 rats were sacrificed from 8 to 24 weeks,10 rats every two weeks.Breast tumors were obtained,hematoxylin and eosin(HE) stain and Factor Ⅷ related antigen(Ⅷ-RAg) immunohistochemistry were performed.Results: Breast tumors were successfully induced in 73 rats,of which 11 rats with benign hyperplasia and 62 rats with breast cancer.Within 62 rats with breast cancer,the histological types included infiltrating duct carcinoma 35 rats,infiltrating lobular carcinoma 15 rats,papillary adenocarcinoma 5 rats,and other tumors 7 rats.Breast cancer was well differentiated in 5 rats,moderately differentiated in 36 rats,and poorly differentiated in 21 rats.MVD was 6.53±2.71 pieces/high power field(HPF) in breast cancer,and 1.67±0.95 pieces /HPF in breast hyperplasia.MVD of breast cancer was significantly higher than that of breast hyperplasia(P0.01).MVD of poorly differentiated cancer was significantly higher than that of well and moderately differentiated cancer(P0.001).Conclusion: Breast cancer can be induced in female Wistar rats successfully with DMBA.MVD of breast cancer is significantly associated with tumor differentiation degree." @default.
- W2356509823 created "2016-06-24" @default.
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- W2356509823 date "2012-01-01" @default.
- W2356509823 modified "2023-09-27" @default.
- W2356509823 title "Observation of microvessel density and histomorphology of DMBA induced rat breast cancer" @default.
- W2356509823 hasPublicationYear "2012" @default.
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