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- W2356511245 abstract "Purified Ca-montmorillonite samples were used as the starting materials to prepare 5-fluorouracil/montmorillonite(5-FU/MMT) complexes under a certain condition.The adsorption of MMT on the 5-FU was investigated.The effects of pH value of release solution and time on in vitro release of the 5-FU were analysed by a dialysis method.Two models of in vitro drug release could be used to simulate the release performance of the 5-FU from the 5-FU/MMT complexes.The release mechanism of the 5-FU and the feasibility of MMT as the sustained-release drug carrier were discussed.The results show that the physical and chemical adsorption and intercalation process are the main interaction between MMT and the 5-FU.It was also indicated that MMT as a good sustained-release drug carrier had a sustained-release effect on the 5-FU.In vitro release ability of the 5-FU from the 5-FU/MMT complexes was affected by pH value of the release solution.The maximum concentration and the in vitro cumulative amount of the 5-FU released from the 5-FU/MMT complexes into pH 1.2 aqueous solutions reached 9.01 mg/L and 23.05%,respectively.The first order kinetics model could be used to describe the variation of in vitro release rate of the 5-FU with time at different pH values,compared to the Korsmeyer–Peppas model.It is suggested that the release process of the 5-FU from the 5-FU/MMT complexes into vari-ous solutions depends on the physical diffusion and drug dissolution,and the ions exchange action between the 5-FU and the release solutions also contributes to the process in some extent." @default.
- W2356511245 created "2016-06-24" @default.
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- W2356511245 date "2010-01-01" @default.
- W2356511245 modified "2023-09-24" @default.
- W2356511245 title "PREPARATION AND RELEASE PERFORMANCE OF FLUOROURACIL/MONTMORILLONITE COMPLEXES" @default.
- W2356511245 hasPublicationYear "2010" @default.
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