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- W2356551204 abstract "OBJECTIVE To investigate the relationship between germ cells apoptosis and alterations of total antioxidant capacity (T-AOC), nitric oxide(NO) level and nitric oxide synthase (NOS) activity in the testes of rats submitted to alcohol drinking. METHODS Twenty healthy male Sprague-Dawley rats (3 months old) were randomly divided into two groups: control group and experimental group. 50% alcohol and distilled water were administered intragastrically at a dose of 10 ml/kg body weight to two groups of rats respectively. After twenty-six days, the biochemical parameters (T-AOC, NO level and NOS activity) were measured with spectrophotometric determination. The TdT-mediated dUTP-X nick end labeling (TUNEL) technique was used to detect germ cells apoptotic index (AI). RESULTS Compared with the control group, AI was significantly higher (P < 0.01) in the experimental group; T-AOC level reduced obviously (P < 0.01), but NO level and NOS activity increased predominantly ( P < 0.01). CONCLUSION The excessive production of NO caused by the increasing of NOS activity and the decreasing of T-AOC may be the main causes that alcohol overtaking induces germ cells apoptosis." @default.
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- W2356551204 date "2006-01-01" @default.
- W2356551204 modified "2023-09-23" @default.
- W2356551204 title "[Relationship between germ cells apoptosis and alterations of total antioxidant capacity, nitric oxide level and nitric oxide synthase activity in testes of rats submitted to alcohol drinking]." @default.
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