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- W2356551926 abstract "Objective To determine the relevance of Fas ligand expression in cervical adenocarcinoma to lymph node metastasis and prognosis,as well as to investigate the cytology mechanisms.Methods There were 14 cases of pelvic lymph node metastases among 35 patients of clinical stage IB and IIB cervical adenocarcinoma.FasL expression in the specimens obtained from surgery was measured using RT-PCR and immunohistochemical staining.The Resultsof FasL expression at mRNA and protein levels were compared semi-quantitatively by optical density.The data of pathological factors and following-up survival rate of patients were analyzed to observe their correlation with FasL expression.Results FasL expression was positive in 62.9%(22/35) of primary lesions,and 92.8%(13/14) of cases with lymph node metastasis.Furthermore,64.3%(9/14) of the metastatic cervical adenocarcinoma in the lymph nodes showed FasL positive staining in more than 50% cancer cells.Pathological analysis indicated that invasion to adjacent tissues and lymph node metastasis correlated closely with the positive FasL expression (P0.01).The five-year survival rate of patients with high FasL-expressing cervical adenocarcinomas significantly reduced to 54.5%(12/22) compared to patients with low FasL-expressing cancers(P0.01).Conclusion FasL-expressing cervical adenocarcinomas could induce apoptosis in tumor infiltrating lymphocytes,which plays an important role in lymph node metastases.FasL allows the cancer cells to evade immune surveillance and then cause worse prognosis." @default.
- W2356551926 created "2016-06-24" @default.
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- W2356551926 date "2006-01-01" @default.
- W2356551926 modified "2023-09-23" @default.
- W2356551926 title "Relevance of fas ligand expression in cervical adenocarcinoma lymph node metastasis and prognosis." @default.
- W2356551926 hasPublicationYear "2006" @default.
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