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- W2356552151 abstract "Objective:To evaluate the effects of human cytomegalovirus(HCMV) infection on human salivary gland duct cell(HSGDC) in vivo and in vitro.Methods: Cell apoptosis in paraffin embeded tissues from 11 cases of parotid cytomegalic inclusion disease(PCID) were detected.The expressions of survivin,proliferating cell nuclear antigen(PCNA) and P53 in these tissues were detected by immunohistochemical method.The effects on the cell cycles of HSGDC infected with HCMV and cultured in vitro were investigated by Flow cytometry.Results: Cell apoptosis detection was negative in all of giant cells with inclusion.Survivin and P53 was not expressed in giant cells with inclusion but weakly expressed in other duct epithelium cells.PCNA was weakly expressed in nucleus of 75% giant cells with inclusion.Compared with mock-infection group,cells percentage in G0/G1 stage of virus-infection group showed significant increase at 36,60,72 h post infection(P=0.000,0.008 and 0.000).Conclusion:After HCMV infection,salivary gland duct epithelial cells didn't develop apoptosis,and the proliferation was blocked in G1 stage." @default.
- W2356552151 created "2016-06-24" @default.
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- W2356552151 date "2011-01-01" @default.
- W2356552151 modified "2023-09-28" @default.
- W2356552151 title "Effect of human cytomegalovirus infection on human salivary gland duct cell" @default.
- W2356552151 hasPublicationYear "2011" @default.
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