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- W2356553414 abstract "Objective This study was to observe osteocyte apoptosis in diabetic periodontitis.Methods Sixty-two six-week-old male SD rats were randomly divided into three groups:diabetic periodontitis group (DP,n=22),periodontitis group (P,n=20) and normal control group (N,n=20). Diabetic rats were induced by intraperitoneal injection of STZ (55mg/kg). Seven days after injection,serum glucose was estimated. Diabetes was defined as serum glucose ≥16.65mmol/L. Periodontitis was initiated by ligating floss around maxillary second molars and oral inoculation with periodontal pathogen Porphyromonas gingivalis. Three or six weeks later,the animals were sacrificed and the specimens were prepared for histological analysis. Assessment was carried out using a number of visual and histological approaches. Histological examination included osteocyte numbers,the percentage of apoptotic osteocytes.Statistical significance was determined by one-way ANOVA with significance set at P0.05.Results The sequence of mean alveolar bone loss among each group was group DPgroup Pgroup N. Intergroup comparisons demonstrated that periodontitis and diabetic periodontitis might reduce the number of osteocytes.Moreover,the number of osteocytes in group DP was also decreased compared with group P (P0.05). Periodontitis and diabetic periodontitis also increased apoptosis of osteocytes. The percentage of apoptotic osteocytes was approximately 2-fold higher in group DP vs. group P.Conclusion The present study clearly demonstrates that diabetes can increase the severity of periodontitis. Accelerated alveolar bone loss was observed in diabetic rats. Diabetes can increase the apoptosis of osteocytes and decrease the number of osteocytes." @default.
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- W2356553414 date "2009-01-01" @default.
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- W2356553414 title "Osteocyte apoptosis in experimental diabetic periodontitis in rats" @default.
- W2356553414 hasPublicationYear "2009" @default.
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