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- W2356553865 abstract "OBJECTIVE To investigate the change and clinical significance of neutrophil volume,conductivity and light scatlering (VCS) parameters in the patients with acute bacterial infection. METHODS The peripheral blood samples from 45 patients with positive blood cultures for bacteria (as test group) and 27 health examination people (as control subjects ) were collected and analyzed,statistically analyzed the data of total white blood cell count(WBC),percentage of neutrophils (N) and the mean VCS parameters generated by the technique of VCS of the Coulter LH 750 hematology analyzer. RESULTS We observed significant increases in the mean neutrophil volume (MNV) and neutrolphil volume distribution width (NDW) and a decrease in the mean neutrophil scattering (MNS) from test group compared with control subjects (P0.05 for all ). Changes in aforesaid parameters were associated with the higher WBC counts and percentages of neutrophils and were present even in patients who did not have leukocytosis or neutrophilia. With a cutoff of 142.2 for the MNV and 19.42 for the NDW,specificities were of 85.2% and 96.3%;sensitivities were of 80% and 97.8%,respectively. The latters were greater than the sensitivities when the cutoffs were 10×109/L for WBC and 0.85 for N (57% and 39%). CONCLUSIONS Significant increases are observed in the MNV and NDW and significant decrease is observed in the MNS,as quantitative ,objective,and more sensitive parameters. We believe the VCS parameters have great values in the diagnosis of acute bacterial infection." @default.
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- W2356553865 date "2010-01-01" @default.
- W2356553865 modified "2023-09-28" @default.
- W2356553865 title "Neutrophil VCS Parameters in Acute Bacterial Infection:Their Change and Clinical Significance" @default.
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